LyoPro Advanced Tray Freeze Dryers

Protocol Development, New Innovative Freeze Dryer Solutions

Analyze, Optimize and Transfer

Focus on your product, not the process.

The LyoPro Advanced Tray Freeze Dryers integrate and maximize the use of 3 powerful innovative tools helping to solve common freeze drying problems.

1. The direct measurement of heat flux with AccuFlux provides a new and valuable tool to understand what is happening within the product itself.  It can be hard to transfer a freeze drying cycle from one freeze dryer to another because of equipment differences and the fact that traditional freeze drying protocol focuses on the shelf temperature and system pressure.  The LyoPro Freeze Dryers focus on the product and determining what the product requires for effective freeze drying.

2.  Optimize your cycle early for the highest through-put in the lab and in manufacturing with AutoDry.  If the freeze drying cycle is not optimized then research and manufacturing costs could be significantly greater then they should be, wasting valuable time and money.

3. Create a homogeneous cake environment that creates synchronized, measurable events with Freeze Booster Controlled Nucleation. Thermal events in the product are often random and difficult to measure and are sometimes missed altogether.

Analyze

Optimize

AutoDry increases the product temperature to its maximum safe temperature as quickly as possible during primary drying without exceeding the product’s critical temperature.   Capacitance manometer and pirani gauge convergence signals the end of primary drying and the system steps into secondary drying automatically.

Transfer

LyoPro freeze dryers provide Kv (vial heat transfer coefficient).  When the heat transfer coefficient of the recepient dryer has been measured and is understood a simple mathematical equation helps determine the target shelf temperature for primary drying.

Because production dryers can seldom be taken off-line once in full operation the Kv is not always understood.  In instances such as this the primary drying time can be extended to create a successful run.

The LyoPro Freeze Dryers are available in 3 basic configurations.

• The MicroFD with LyoSim.  For researchers who want to do R&D with as few as 7 vials.  Exceptionally small batch runs provide fast turn-around and optimum lab throughput.
• The RevoPro Freeze Dryer.  Researchers who want to perform full laboratory tray dryer runs.  This unit is available with 1 to 5 shelves and 2 to 10 sq ft of shelf surface area.
• The MagnumPro Freeze Dryer provides pilot scale through-put but can also be utilized for R&D.  The MagnumPro is ideal for processing larger batches but also being able to analyze, optimize and develop transfer cycles.

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